Role of receptor for advanced glycation end-products and signalling events in advanced glycation end-product-induced monocyte chemoattractant protein-1 expression in differentiated mouse podocytes | Zendy

Leyi Gu | Zendy; Shinji Hagiwara | Zendy; Qiuling Fan | Zendy; Mitsuo Tanimoto | Zendy; Mami Kobata | Zendy; M Yamashita | Zendy; Tomohito Nishitani | Zendy; Tomohito Gohda | Zendy; Zhaohui Ni | Zendy; Jiaqi Qian | Zendy; Satoshi Horikoshi | Zendy; Yasuhiko Tomino | Zendy

Open Access

Role of receptor for advanced glycation end-products and signalling events in advanced glycation end-product-induced monocyte chemoattractant protein-1 expression in differentiated mouse podocytes

Author(s) -

Leyi Gu,

Shinji Hagiwara,

Qiuling Fan,

Mitsuo Tanimoto,

Mami Kobata,

M Yamashita,

Tomohito Nishitani,

Tomohito Gohda,

Zhaohui Ni,

Jiaqi Qian,

Satoshi Horikoshi,

Yasuhiko Tomino

Publication year - 2005

Publication title -

nephrology dialysis transplantation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.654

H-Index - 168

eISSN - 1460-2385

pISSN - 0931-0509

DOI - 10.1093/ndt/gfi210

Subject(s) - glycation , advanced glycation end product , rage (emotion) , mapk/erk pathway , kinase , microbiology and biotechnology , podocyte , downregulation and upregulation , monocyte , signal transduction , receptor , cancer research , biology , endocrinology , medicine , biochemistry , kidney , neuroscience , proteinuria , gene

Upregulation of local monocyte chemoattractant protein-1 (MCP-1) production is involved in glomerular damage through macrophage recruitment and activation in diabetic nephropathy. Treatment of db/db mice with soluble receptor for advanced glycation end-products (RAGE) prevented recruitment of macrophages to the glomeruli and reduced albuminuria, suggesting that binding of ligands and RAGE may be involved in MCP-1 expression. Therefore, we investigated the role of advanced glycation end-products (AGEs) in MCP-1 production by podocytes and signalling events after RAGE activation.

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