Effects of NH4Cl intake on renal growth in rats: role of MAPK signalling pathway | Zendy

Leda Márcia Araújo Bento | Zendy; José Barreto Campello Carvalheira | Zendy; Leonardo Fantinato Menegon | Zendy; Mário J. A. Saad | Zendy; José Antônio Rocha Gontijo | Zendy

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Effects of NH4Cl intake on renal growth in rats: role of MAPK signalling pathway

Author(s) -

Leda Márcia Araújo Bento,

José Barreto Campello Carvalheira,

Leonardo Fantinato Menegon,

Mário J. A. Saad,

José Antônio Rocha Gontijo

Publication year - 2005

Publication title -

nephrology dialysis transplantation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.654

H-Index - 168

eISSN - 1460-2385

pISSN - 0931-0509

DOI - 10.1093/ndt/gfi133

Subject(s) - medicine , mapk/erk pathway , endocrinology , microbiology and biotechnology , signal transduction , biology

There is a surprising lack of experimental data on the mechanisms of NH4Cl-induced chronic metabolic acidosis which causes kidney hypertrophy. The NH4Cl treatment results in an absolute increase in kidney mass. Despite findings to indicate a close interaction between NH4Cl-induced chronic metabolic acidosis and renal enlargement, the role of the stimulated serine kinase cascade, mediated by the stepwise activation of extracellular signal-regulated kinase (ERK) signalling, on kidney hypertrophy has not yet been investigated.

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