Open AccessIron chelators do not reduce cold-induced cell injury in the isolated perfused rat kidney model
Author(s) -
Miranda Bartels-Stringer,
Jack F.M. Wetzels,
Alfons C. Wouterse,
Eric Steenbergen,
Frans G. M. Rüssel,
Cornelis Kramers
Publication year - 2005
Publication title -
nephrology dialysis transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.654
H-Index - 168
eISSN - 1460-2385
pISSN - 0931-0509
DOI - 10.1093/ndt/gfi127
Subject(s) - kidney , perfusion , cold storage , renal function , medicine , viaspan , deferoxamine , chelation , oxygen , pharmacology , chemistry , biology , transplantation , organic chemistry , horticulture
In vitro, cold-induced injury is an important contributor to renal tubular cell damage. It is mediated by iron-dependent formation of reactive oxygen species and can be prevented by iron chelation. We studied whether iron chelators can prevent cold-induced damage in the isolated perfused rat kidney (IPK) model both after cold perfusion (CP) and after cold storage (CS). We hypothesized that in the CP model iron-dependent cold-induced injury is more pronounced, since oxygen is constantly provided.
Accelerating Research
Robert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom
Address
John Eccles HouseRobert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom