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In a study initially designed to evaluate the specific protein gene product 9.5 expression in parietal epithelial cells of Bowman's capsule, a marked positivity was also observed in the tubular and collecting duct epithelial cells. Since protein gene product 9.5 is an important enzyme in the ubiquitin system of proteolysis, and plays a regulatory role in cell cycle and proliferation, its presence in specific segments of the nephron was of considerable interest.

Protein gene product 9.5 and ubiquitin are expressed in metabolically active epithelial cells of normal and pathologic human kidney