Protein gene product 9.5 and ubiquitin are expressed in metabolically active epithelial cells of normal and pathologic human kidney | Zendy

Francesca DiomediCamassei | Zendy; Lucilla Ravà | Zendy; Evelyne Lerut | Zendy; Francesco Callea | Zendy; Boudewijn Van Damme | Zendy

Open Access

Protein gene product 9.5 and ubiquitin are expressed in metabolically active epithelial cells of normal and pathologic human kidney

Author(s) -

Francesca DiomediCamassei,

Lucilla Ravà,

Evelyne Lerut,

Francesco Callea,

Boudewijn Van Damme

Publication year - 2005

Publication title -

nephrology dialysis transplantation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.654

H-Index - 168

eISSN - 1460-2385

pISSN - 0931-0509

DOI - 10.1093/ndt/gfi124

Subject(s) - proteolysis , gene product , nephron , kidney , ubiquitin , medicine , gene , gene expression , epithelium , microbiology and biotechnology , enzyme , pathology , cancer research , biology , endocrinology , biochemistry

In a study initially designed to evaluate the specific protein gene product 9.5 expression in parietal epithelial cells of Bowman's capsule, a marked positivity was also observed in the tubular and collecting duct epithelial cells. Since protein gene product 9.5 is an important enzyme in the ubiquitin system of proteolysis, and plays a regulatory role in cell cycle and proliferation, its presence in specific segments of the nephron was of considerable interest.

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