Early proximal tubule injury in experimental aristolochic acid nephropathy: functional and histological studies | Zendy

Catherine Lebeau | Zendy; Frederic Debellé | Zendy; Volker M. Arlt | Zendy; Agnieszka Pozdzik | Zendy; Eric G. De Prez | Zendy; David H. Phillips | Zendy; M Deschodt-Lanckman | Zendy; JeanLouis Vanherweghem | Zendy; Joëlle Nortier | Zendy

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Early proximal tubule injury in experimental aristolochic acid nephropathy: functional and histological studies

Author(s) -

Catherine Lebeau,

Frederic Debellé,

Volker M. Arlt,

Agnieszka Pozdzik,

Eric G. De Prez,

David H. Phillips,

M Deschodt-Lanckman,

JeanLouis Vanherweghem,

Joëlle Nortier

Publication year - 2005

Publication title -

nephrology dialysis transplantation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.654

H-Index - 168

eISSN - 1460-2385

pISSN - 0931-0509

DOI - 10.1093/ndt/gfi042

Subject(s) - aristolochic acid , medicine , kidney , nephropathy , aminopeptidase , urinary system , endocrinology , in vivo , brush border , pathology , leucine , biochemistry , biology , amino acid , diabetes mellitus , vesicle , genetics , microbiology and biotechnology , membrane

Aristolochic acid (AA), the plant extract of Aristolochia species, is involved in the onset of progressive tubulointerstitial renal fibrosis in humans. Clinical and in vitro findings have previously suggested that the proximal tubule was the target of AA.

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