Dose-reducing H2 receptor antagonists in the presence of low glomerular filtration rate: a systematic review of the evidence | Zendy

Jaimie Manlucu | Zendy; Marcello Tonelli | Zendy; Joel G. Ray | Zendy; Αλεξάνδρα Παπαϊωάννου | Zendy; George Youssef | Zendy; Heather ThiessenPhilbrook | Zendy; Anne Holbrook | Zendy; Amit X. Garg | Zendy

Open Access

Dose-reducing H2 receptor antagonists in the presence of low glomerular filtration rate: a systematic review of the evidence

Author(s) -

Jaimie Manlucu,

Marcello Tonelli,

Joel G. Ray,

Αλεξάνδρα Παπαϊωάννου,

George Youssef,

Heather ThiessenPhilbrook,

Anne Holbrook,

Amit X. Garg

Publication year - 2005

Publication title -

nephrology dialysis transplantation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.654

H-Index - 168

eISSN - 1460-2385

pISSN - 0931-0509

DOI - 10.1093/ndt/gfi025

Subject(s) - medicine , renal function , adverse effect , confidence interval , pharmacokinetics , cohort , randomized controlled trial , meta analysis , cohort study , drug , urology , pharmacology

While it is recommended that H2 receptor antagonists (H2RAs) be dose reduced in the presence of low glomerular filtration rate (GFR), in practice such adjustments often do not occur. We reviewed the evidence for this recommendation.

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