Open AccessTailoring high-cut-off membranes and feasible application in sepsis-associated acute renal failure: in vitro studies
Author(s) -
Filippo Mariano,
Valentina Fonsato,
Giacomo Lanfranco,
Robert Pohlmeier,
Claudio Ronco,
Giorgio Triolo,
Giovanni Camussi,
Ciro Tetta,
Jutta PasslickDeetjen
Publication year - 2005
Publication title -
nephrology dialysis transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.654
H-Index - 168
eISSN - 1460-2385
pISSN - 0931-0509
DOI - 10.1093/ndt/gfh776
Subject(s) - medicine , albumin , cytokine , membrane , in vitro , extracorporeal , permeability (electromagnetism) , sepsis , immunology , biochemistry , chemistry
As removal of pro-inflammatory cytokines is limited in conventional diffusive or convective extracorporeal therapies, we studied in two polysulphone membranes with an industrial albumin sieving coefficient of 0.05 (Type A) and 0.13 (Type B) cytokine (IL-6, IL-8, IL-1beta, IL-1ra, TNF-alpha) and plasma protein (albumin, cystatin C, total proteins) permeability profiles. Based on the convective membrane permeability, we evaluated in vitro the dialytic modality that could provide an acceptable balance between high cytokine and low albumin clearances.
Accelerating Research
Robert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom
Address
John Eccles HouseRobert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom