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44: 974–981 51. Traupe T, Muenter K, Barton M. Impaired sodium and potassium excretion with aging is regulated by increased endothelin. Circulation 2002; 106 [Suppl II]: 684 52. Amaral SL, Papanek PE, Greene AS. Angiotensin II and VEGF are involved in angiogenesis induced by short-term exercise training. Am J Physiol 2001; 281: H1163–H1169 53. Shimada T, Takeshita Y, Murohara T et al. Angiogenesis and vasculogenesis are impaired in the precocious-aging klotho mouse. Circulation 2004; 110: 1148–1155 54. Zeiher AM, Drexler H, Saurbier B, Just H. Endotheliummediated coronary blood flow modulation in humans. Effects of age, atherosclerosis, hypercholesterolemia, and hypertension. J Clin Invest 1993; 92: 652–662 55. Taddei S, Virdis A, Mattei P et al. Hypertension causes premature aging of endothelial function in humans. Hypertension 1997; 29: 736–743 56. Singh N, Prasad S, Singer DR, MacAllister RJ. Ageing is associated with impairment of nitric oxide and prostanoid dilator pathways in the human forearm. Clin Sci (Lond) 2002; 102: 595–600 57. Jensen-Urstad K, Bouvier F, Jensen-Urstad M. Preserved vascular reactivity in elderly male athletes. Scand J Med Sci Sports 1999; 9: 88–91 58. Green D, Cheetham C, Mavaddat L et al. Effect of lower limb exercise on forearm vascular function: contribution of nitric oxide. Am J Physiol 2002; 283: H899–H907 59. Mazzeo RS, Tanaka H. Exercise prescription for the elderly: current recommendations. Sports Med 2001; 31: 809–818 60. Barton M, Furrer J. Cardiovascular consequences of the obesity pandemic: need for action. Exp Opin Invest Drugs 2003; 12: 1757–1759 61. Jarvisalo MJ, Harmoinen A, Hakanen M et al. Elevated serum C-reactive protein levels and early arterial changes in healthy children. Arterioscler Thromb Vasc Biol 2002; 22: 1323–1328 62. Schachinger V, Britten MB, Zeiher AM. Prognostic impact of coronary vasodilator dysfunction on adverse long-term outcome of coronary heart disease. Circulation 2000; 101: 1899–1906 63. Suwaidi JA, Hamasaki S, Higano ST, Nishimura RA, Holmes DR Jr, Lerman A. Long-term follow-up of patients with mild coronary artery disease and endothelial dysfunction. Circulation 2000; 101: 948–954

Why patients with progressing kidney disease are referred late to the nephrologist: on causes and proposals for improvement