Impairment of glutathione biosynthetic pathway in uraemia and dialysis | Zendy

Mohamed-Saiel Saeed Alhamdani | Zendy

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Impairment of glutathione biosynthetic pathway in uraemia and dialysis

Author(s) -

Mohamed-Saiel Saeed Alhamdani

Publication year - 2005

Publication title -

nephrology dialysis transplantation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.654

H-Index - 168

eISSN - 1460-2385

pISSN - 0931-0509

DOI - 10.1093/ndt/gfh569

Subject(s) - glutathione , continuous ambulatory peritoneal dialysis , medicine , peritoneal dialysis , hemodialysis , dialysis , endocrinology , malondialdehyde , oxidative stress , nephrology , biochemistry , enzyme , chemistry

Glutathione (GSH), the predominant intracellular antioxidant, reportedly has been shown to be decreased in chronic renal failure patients, which renders these patients more susceptible to oxidative damage by free radicals. To our knowledge, the ability of erythrocytes to normalize the GSH level by de novo synthesis in uraemic and dialysis patients has not been studied previously. The main goal of the present study was to measure the activities of the enzymes that are responsible for de novo GSH generation, namely gamma-glutamylcysteine synthetase (gamma-GCS) and glutathione synthetase (GSH-S), in erythrocytes from uraemic and dialysis patients.

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