Impaired release of interleukin-6 from human osteoblastic cells in the uraemic milieu | Zendy

Simon Steddon | Zendy; Christopher W. McIntyre | Zendy; Neil J. Schroeder | Zendy; J. M. Burrin | Zendy; John Cunningham | Zendy

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Impaired release of interleukin-6 from human osteoblastic cells in the uraemic milieu

Author(s) -

Simon Steddon,

Christopher W. McIntyre,

Neil J. Schroeder,

J. M. Burrin,

John Cunningham

Publication year - 2004

Publication title -

nephrology dialysis transplantation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.654

H-Index - 168

eISSN - 1460-2385

pISSN - 0931-0509

DOI - 10.1093/ndt/gfh491

Subject(s) - medicine , endocrinology , dialysis , cytokine , hemodialysis , bone resorption , bone remodeling , incubation , renal osteodystrophy , osteoblast , uremia , interleukin , kidney disease , in vitro , biochemistry , chemistry

Osteoblast-derived interleukin-6 (IL-6) affects bone metabolism and is linked with a number of pathological states characterized by increased bone resorption, including osteoporosis and renal osteodystrophy. To examine the possibility that uraemia directly influences the release of this cytokine in bone, we have investigated the effect of human uraemic serum on the release of IL-6 from human osteoblast-like cells.

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