4-Heptanone is a metabolite of the plasticizer di(2-ethylhexyl) phthalate (DEHP) in haemodialysis patients | Zendy

Hans Günther Wahl | Zendy; Hong Qian | Zendy; Sibylle Hildenbrand | Zendy; T. Risler | Zendy; D. Luft | Zendy; H.M. Liebich | Zendy

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4-Heptanone is a metabolite of the plasticizer di(2-ethylhexyl) phthalate (DEHP) in haemodialysis patients

Author(s) -

Hans Günther Wahl,

Hong Qian,

Sibylle Hildenbrand,

T. Risler,

D. Luft,

H.M. Liebich

Publication year - 2004

Publication title -

nephrology dialysis transplantation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.654

H-Index - 168

eISSN - 1460-2385

pISSN - 0931-0509

DOI - 10.1093/ndt/gfh425

Subject(s) - phthalate , metabolite , urine , medicine , hemodialysis , diabetes mellitus , population , endocrinology , benzhydryl compounds , physiology , pharmacology , chemistry , environmental health , organic chemistry , bisphenol a , epoxy

There is an ongoing discussion about the risks of di(2-ethylhexyl) phthalate (DEHP) exposure for the general population as well as for specific subgroups in various medical settings. Haemodialysis patients certainly belong to the group with the highest exposure taking into account the repeated treatments over a long period of time. Many studies have shown that DEHP metabolites are more active with regard to cellular responses than DEHP itself. Although 4-heptanone has been shown to be a DEHP metabolite in rats, this has never been tested in humans. On the other hand, 4-heptanone was reported to be associated with diabetes mellitus.

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