Inhibition of brush border dipeptidase with cilastatin reduces toxic accumulation of cyclosporin A in kidney proximal tubule epithelial cells | Zendy

María Dolores Pérez | Zendy; María Luisa Dotor Castilla | Zendy; Ana M. Torres | Zendy; J. A. Lazaro | Zendy; E. Sarmiento | Zendy; Alberto Tejedor | Zendy

Open Access

Inhibition of brush border dipeptidase with cilastatin reduces toxic accumulation of cyclosporin A in kidney proximal tubule epithelial cells

Author(s) -

María Dolores Pérez,

María Luisa Dotor Castilla,

Ana M. Torres,

J. A. Lazaro,

E. Sarmiento,

Alberto Tejedor

Publication year - 2004

Publication title -

nephrology dialysis transplantation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.654

H-Index - 168

eISSN - 1460-2385

pISSN - 0931-0509

DOI - 10.1093/ndt/gfh397

Subject(s) - medicine , nephrotoxicity , brush border , kidney , urology , pharmacology , endocrinology , pathology , biochemistry , biology , vesicle , membrane

Cilastatin reduces nephrotoxicity associated with cyclosporin A (CyA) in solid organ and bone marrow transplantation. This appears to be unrelated to changes in renal haemodynamics or CyA metabolism. How cilastatin induces this protection is unclear, but it could result from changes on accumulation of CyA proximal cells.

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