Dual blockade of the renin-angiotensin system compared with a 50% increase in the dose of angiotensin-converting enzyme inhibitor: effects on proteinuria and blood pressure | Zendy

Priscilla KincaidSmith | Zendy; K. F. Fairley | Zendy; David Packham | Zendy

Open Access

Dual blockade of the renin-angiotensin system compared with a 50% increase in the dose of angiotensin-converting enzyme inhibitor: effects on proteinuria and blood pressure

Author(s) -

Priscilla KincaidSmith,

K. F. Fairley,

David Packham

Publication year - 2004

Publication title -

nephrology dialysis transplantation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.654

H-Index - 168

eISSN - 1460-2385

pISSN - 0931-0509

DOI - 10.1093/ndt/gfh384

Subject(s) - candesartan , medicine , proteinuria , blood pressure , ace inhibitor , angiotensin converting enzyme , endocrinology , angiotensin ii , creatinine , angiotensin receptor , urology , pharmacology , kidney

Several publications in the past 2 years have demonstrated that combined angiotensin-converting enzyme inhibitors (ACEI) and angiotensin-II receptor antagonist (AIIRA) are more effective in reducing blood pressure and proteinuria in patients with chronic renal disease than ACEI or AIIRA alone. This study compares the effect of increasing the ACEI dose by 50% with that of adding an AIIRA to a standard ACEI dose.

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