Serum osteoprotegerin levels and the extent of vascular calcification in haemodialysis patients | Zendy

Kosaku Nitta | Zendy; T. Akiba | Zendy; K. Uchida | Zendy; Shigeru Otsubo | Zendy; Takashi Takei | Zendy; Wako Yumura | Zendy; Takashi Kabaya | Zendy; H Nihei | Zendy

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Serum osteoprotegerin levels and the extent of vascular calcification in haemodialysis patients

Author(s) -

Kosaku Nitta,

T. Akiba,

K. Uchida,

Shigeru Otsubo,

Takashi Takei,

Wako Yumura,

Takashi Kabaya,

H Nihei

Publication year - 2004

Publication title -

nephrology dialysis transplantation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.654

H-Index - 168

eISSN - 1460-2385

pISSN - 0931-0509

DOI - 10.1093/ndt/gfh263

Subject(s) - osteoprotegerin , medicine , calcification , osteoclast , calcinosis , osteopontin , osteoporosis , endocrinology , hemodialysis , receptor , activator (genetics)

Osteoprotegerin (OPG) is a glycoprotein that inhibits osteoclast differentiation and activity. OPG-deficient mice develop severe osteoporosis and medial arterial calcification. The expression of OPG is detected in early atherosclerotic lesions in non-uraemic patients. We examined whether serum OPG is associated with aortic calcification in haemodialysis patients.

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