Activation of matrix metalloproteinase-2 causes peritoneal injury during peritoneal dialysis in rats | Zendy

Ichiro Hirahara | Zendy; Yumi Ogawa | Zendy; Eiji Kusano | Zendy; Yasushi Asano | Zendy

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Activation of matrix metalloproteinase-2 causes peritoneal injury during peritoneal dialysis in rats

Author(s) -

Ichiro Hirahara,

Yumi Ogawa,

Eiji Kusano,

Yasushi Asano

Publication year - 2004

Publication title -

nephrology dialysis transplantation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.654

H-Index - 168

eISSN - 1460-2385

pISSN - 0931-0509

DOI - 10.1093/ndt/gfh262

Subject(s) - zymography , medicine , peritoneal dialysis , peritoneum , matrix metalloproteinase , peritonitis , pathology , peritoneal cavity , continuous ambulatory peritoneal dialysis , peritoneal equilibration test , gelatin , surgery , biochemistry , biology

Sclerosing peritonitis (SP) and encapsulating peritoneal sclerosis (EPS) are serious complications of continuous ambulatory peritoneal dialysis. Although we have shown previously that matrix metalloproteinase-2 (MMP-2) is increased in peritoneal injury leading to SP/EPS, most of the MMP-2 in the dialysate drained from the peritoneal cavity was the latent form that was lacking activity. In the present study, we investigated whether MMP-2 causes peritoneal injury.

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