Open AccessAbnormal mitochondrial function and muscle wasting, but normal contractile efficiency, in haemodialysed patients studied non-invasively in vivo
Author(s) -
Graham J. Kemp,
Alexander Crowe,
Hameed Anijeet,
Qiyong Gong,
William E. Bimson,
Simon P. Frostick,
J. M. Bone,
Gordon M. Bell,
Jeremy Roberts
Publication year - 2004
Publication title -
nephrology dialysis transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.654
H-Index - 168
eISSN - 1460-2385
pISSN - 0931-0509
DOI - 10.1093/ndt/gfh189
Subject(s) - phosphocreatine , medicine , isometric exercise , wasting , magnetic resonance imaging , endocrinology , mitochondrial disease , bicarbonate , gastrocnemius muscle , skeletal muscle , cardiology , mitochondrial dna , chemistry , radiology , energy metabolism , gene , biochemistry
Muscle dysfunction, which contributes to morbidity in patients on haemodialysis, has several manifestations and a number of possible causes. We applied the non-invasive techniques of (31)P-magnetic resonance spectroscopy ((31)P-MRS), magnetic resonance imaging (MRI) and near-infrared spectroscopy (NIRS) to calf muscle of dialysed patients to define the abnormalities in muscle cross-sectional area (CSA), contractile efficiency, mitochondrial function and vascular O(2) supply.
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