Open AccessInflammation and resistance to erythropoiesis-stimulating agents—what do we know and what needs to be clarified?
Author(s) -
Jana Smržová,
József Balla,
Peter Bárány
Publication year - 2005
Publication title -
nephrology dialysis transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.654
H-Index - 168
eISSN - 1460-2385
pISSN - 0931-0509
DOI - 10.1093/ndt/gfh1109
Subject(s) - medicine , erythropoiesis , kidney disease , inflammation , intensive care medicine , etiology , disease , immunology , anemia
Resistance to erythropoiesis-stimulating agents (ESA) in patients with chronic kidney disease (CKD) can be associated with evidence of enhanced systemic inflammatory responses. This review considers the inflammatory mechanisms thought to be involved in the development and aetiology of anaemia of CKD that may help our understanding and management of patients with ESA resistance. The potential role of nutritional support and of anti-inflammatory therapies in managing resistance to ESA therapy is discussed and explored.
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