Correction of metabolic acidosis improves thyroid and growth hormone axes in haemodialysis patients | Zendy

Manuel Wiederkehr | Zendy; J. Kalogiros | Zendy; Reto Krapf | Zendy

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Correction of metabolic acidosis improves thyroid and growth hormone axes in haemodialysis patients

Author(s) -

Manuel Wiederkehr,

J. Kalogiros,

Reto Krapf

Publication year - 2004

Publication title -

nephrology dialysis transplantation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.654

H-Index - 168

eISSN - 1460-2385

pISSN - 0931-0509

DOI - 10.1093/ndt/gfh096

Subject(s) - medicine , endocrinology , metabolic acidosis , acidosis , bicarbonate , dialysis

Chronic metabolic acidosis (CMA) in normal adults results in complex endocrine and metabolic alterations including growth hormone (GH) insensitivity, hypothyroidism, hyperglucocorticoidism, hypoalbuminaemia and loss of protein stores. Similar alterations occur in chronic renal failure, a prototypical state of CMA. We evaluated whether metabolic acidosis contributes to the endocrine and metabolic alterations characteristic of end-stage renal disease.

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