Open AccessThrombotic microangiopathy associated with unusual viral sequences in HIV-1-positive patients
Author(s) -
Friederike Jochimsen,
W. Gruening,
Thierry Arnould,
Mark S. Segal,
Margot S. Kruskall,
R. Colgrove,
Gerd Walz
Publication year - 2004
Publication title -
nephrology dialysis transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.654
H-Index - 168
eISSN - 1460-2385
pISSN - 0931-0509
DOI - 10.1093/ndt/gfh085
Subject(s) - tropism , virology , thrombotic microangiopathy , viral envelope , tissue tropism , viral load , gp41 , viral entry , medicine , endothelial activation , virus , viral replication , immunology , biology , antibody , inflammation , pathology , epitope , disease
Thrombotic microangiopathy (TMA) is a rare disorder caused by endothelial cell damage. TMA has been associated with the human immunodeficiency virus 1 (HIV-1) infection, yet only a minority of all HIV-1 patients develops TMA. Since HIV-1 has been shown to interact with endothelial cells, we investigated whether certain mutations in the HIV-1 envelope protein are associated with the development of TMA in HIV-1-infected patients.
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