Melatonin decreases apoptosis and expression of apoptosis-associated proteins in acute puromycin aminonucleoside nephrosis | Zendy

Adriana Pedreáñez | Zendy; J. Rincón | Zendy; Maritza J. Romero | Zendy; Ninoska T. Viera | Zendy; Jesús Mosquera | Zendy

Open Access

Melatonin decreases apoptosis and expression of apoptosis-associated proteins in acute puromycin aminonucleoside nephrosis

Author(s) -

Adriana Pedreáñez,

J. Rincón,

Maritza J. Romero,

Ninoska T. Viera,

Jesús Mosquera

Publication year - 2004

Publication title -

nephrology dialysis transplantation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.654

H-Index - 168

eISSN - 1460-2385

pISSN - 0931-0509

DOI - 10.1093/ndt/gfh068

Subject(s) - nephrosis , apoptosis , endocrinology , medicine , malondialdehyde , fas ligand , puromycin , lipid peroxidation , superoxide dismutase , oxidative stress , melatonin , tunel assay , biology , microbiology and biotechnology , biochemistry , programmed cell death , protein biosynthesis

The anti-apoptotic properties of melatonin have been demonstrated previously in several in vivo and in vitro studies. Previous reports have shown increased apoptosis during puromycin aminonucleoside nephrosis (PAN). The aim of this study was to determine if melatonin (MEL) can prevent apoptosis and modify oxidative stress, an apoptosis inducer, in this experimental model.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research