Expression of -actinin-4 in acquired human nephrotic syndrome: a quantitative immunoelectron microscopy study | Zendy

N. P. Goode | Zendy; Mike Shires | Zendy; Tahir Naeem Khan | Zendy; Aisling Mooney | Zendy

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Expression of -actinin-4 in acquired human nephrotic syndrome: a quantitative immunoelectron microscopy study

Author(s) -

N. P. Goode,

Mike Shires,

Tahir Naeem Khan,

Aisling Mooney

Publication year - 2004

Publication title -

nephrology dialysis transplantation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.654

H-Index - 168

eISSN - 1460-2385

pISSN - 0931-0509

DOI - 10.1093/ndt/gfg620

Subject(s) - immunoelectron microscopy , podocyte , nephrotic syndrome , microbiology and biotechnology , actin cytoskeleton , transmembrane protein , cytoskeleton , actin , medicine , signal transduction , renal glomerulus , phenotype , glomerulonephritis , immunology , biology , kidney , cell , genetics , gene , antibody , receptor , proteinuria

The molecular basis for the alteration of glomerular podocyte phenotype in nephrotic syndrome probably involves adaptive changes of the actin cytoskeleton. alpha-Actinin-4 is an actin cross-linking protein that also interacts with intra- and intercellular adhesion molecules and elements of the transmembrane signal transduction pathway and is implicated in nephrotic syndrome by animal models and human genetic studies.

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