Open AccessIncreased levels of N -(carboxymethyl)lysine and N -(carboxyethyl)lysine in type 1 diabetic patients with impaired renal function: correlation with markers of endothelial dysfunction
Author(s) -
Mariska Lieuw-a-Fa,
Victor W.M. van Hinsbergh,
Tom Teerlink,
Rob Barto,
Jos W. R. Twisk,
Coen D.A. Stehouwer,
Casper G. Schalkwijk
Publication year - 2004
Publication title -
nephrology dialysis transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.654
H-Index - 168
eISSN - 1460-2385
pISSN - 0931-0509
DOI - 10.1093/ndt/gfg619
Subject(s) - medicine , plasminogen activator , renal function , endocrinology , glycation , endothelial dysfunction , von willebrand factor , diabetes mellitus , thrombomodulin , plasminogen activator inhibitor 1 , kidney disease , platelet , thrombin
Diabetic and non-diabetic patients with renal failure have an increased risk for cardiovascular disease, which may be the result of uraemic toxins, including advanced glycation end-products (AGEs). The aim of the study was to investigate the levels of well-characterized AGEs, N(epsilon)-(carboxymethyl)lysine (CML) and N(epsilon)-(carboxyethyl)lysine (CEL) in relation to kidney function and to study the relationship of these AGEs to endothelial function and inflammation in type 1 diabetic patients.
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