Dexamethasone regulates AP-1 to repress TNF- induced MCP-1 production in human glomerular endothelial cells | Zendy

SunKyeong Park | Zendy

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Dexamethasone regulates AP-1 to repress TNF- induced MCP-1 production in human glomerular endothelial cells

Author(s) -

SunKyeong Park

Publication year - 2004

Publication title -

nephrology dialysis transplantation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.654

H-Index - 168

eISSN - 1460-2385

pISSN - 0931-0509

DOI - 10.1093/ndt/gfg583

Subject(s) - microbiology and biotechnology , western blot , tumor necrosis factor alpha , monocyte , nfkb1 , electrophoretic mobility shift assay , medicine , endocrinology , biology , gene expression , biochemistry , gene , transcription factor

Glomerular endothelial cells play a role in the pathogenesis of glomerulonephritis by producing chemotactic factors. We investigated the role of NF-kappa B and AP-1 in tumour necrosis factor alpha (TNF-alpha) induced monocyte chemoattractant protein 1 (MCP-1) production in cultured human glomerular endothelial cells (HGEC). We also examined whether or not these processes could be modified by glucocorticoid.

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