Open AccessExpression of human nephrin mRNA in diabetic nephropathy
Author(s) -
Masao Toyoda
Publication year - 2004
Publication title -
nephrology dialysis transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.654
H-Index - 168
eISSN - 1460-2385
pISSN - 0931-0509
DOI - 10.1093/ndt/gfg545
Subject(s) - nephrin , slit diaphragm , medicine , podocyte , microalbuminuria , diabetic nephropathy , messenger rna , endocrinology , nephropathy , diabetes mellitus , proteinuria , kidney , gene , biology , genetics
Diabetic nephropathy (DN) is associated with functional changes in the filtration barrier, and microalbuminuria is a strong predictor of the development of overt DN. Nephrin is a novel podocyte-specific protein which localizes at the slit diaphragm. This study examines the expression of nephrin mRNA in the kidneys of type 2 diabetics with DN.
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