Hypochlorous acid and low serum paraoxonase activity in haemodialysis patients: an in vitro study | Zendy

W. H. F. Sutherland | Zendy; Sylvia A. de Jong | Zendy; Rob Walker | Zendy

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Hypochlorous acid and low serum paraoxonase activity in haemodialysis patients: an in vitro study

Author(s) -

W. H. F. Sutherland,

Sylvia A. de Jong,

Rob Walker

Publication year - 2003

Publication title -

nephrology dialysis transplantation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.654

H-Index - 168

eISSN - 1460-2385

pISSN - 0931-0509

DOI - 10.1093/ndt/gfg484

Subject(s) - hypochlorous acid , paraoxonase , pon1 , arylesterase , chemistry , lipoprotein , taurine , hydrogen peroxide , biochemistry , aryldialkylphosphatase , medicine , endocrinology , enzyme , cholesterol , amino acid , genotype , gene

Serum paraoxonase 1 (PON1) is an oxidant-sensitive enzyme associated with high-density lipoprotein (HDL) that inhibits the atherogenic oxidation of low-density lipoprotein (LDL). In haemodialysis patients, production of reactive oxygen species, such as hypochlorous acid (HOCl) and hydrogen peroxide, is increased and serum PON1 arylesterase is abnormally low. We have examined the effect of HOCl and the uraemic milieu on serum PON1 arylesterase activity and the ability of HDL to inhibit LDL oxidation in vitro.

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