Open AccessHypoalbuminaemia enhances the renal vasoconstrictor effect of lysophosphatidylcholine
Author(s) -
Thi Danh Vuong
Publication year - 2003
Publication title -
nephrology dialysis transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.654
H-Index - 168
eISSN - 1460-2385
pISSN - 0931-0509
DOI - 10.1093/ndt/gfg238
Subject(s) - lysophosphatidylcholine , vasoconstriction , medicine , renal blood flow , endocrinology , kidney , renal circulation , chemistry , phospholipid , phosphatidylcholine , biochemistry , membrane
Lysophosphatidylcholine (LPC) causes vascular dysfunction in vitro. Lipoprotein LPC is increased in hypoalbuminaemia. Albumin binds LPC and restores LPC-induced abnormalities. We hypothesized that in vivo LPC impairs blood flow more in hypoalbuminaemia than in normoalbuminaemia.
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