Open AccessOxidative stress-related factors in Bartter's and Gitelman's syndromes: relevance for angiotensin II signalling
Author(s) -
Lorenzo A. Calò
Publication year - 2003
Publication title -
nephrology dialysis transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.654
H-Index - 168
eISSN - 1460-2385
pISSN - 0931-0509
DOI - 10.1093/ndt/gfg204
Subject(s) - oxidative stress , endocrinology , medicine , angiotensin ii , gitelman syndrome , intracellular , bartter syndrome , oxidative phosphorylation , stimulation , renin–angiotensin system , inositol , receptor , biochemistry , biology , chemistry , hypomagnesemia , hypokalemia , blood pressure , organic chemistry , magnesium
Bartter's and Gitelman's syndromes (BS/GS) have a blunted Gq protein-mediated cell signalling despite high circulating angiotensin II (Ang II) levels. This is associated with reduced Galphaq gene expression, intracellular inositol trisphosphate and Ca(++) release, PKC activity and cell reactivity. Ang II is a powerful stimulator of vascular oxidases but BS/GS patients show reduced total volatile LDL oxidation products and reduced LDL susceptibility to oxidation suggesting low level of oxidative stress. Therefore, we evaluated oxidative stress-related proteins in plasma and monocytes of patients with BS/GS, at baseline and after Ang II stimulation.
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