Role of insulin and the IGF system in renal hypertrophy in diabetic Psammomys obesus (sand rat) | Zendy

Itamar Raz | Zendy; Isaiah D. Wexler | Zendy; O Weiss | Zendy; A. Flyvbjerg | Zendy; Yael Segev | Zendy; Adina S. Rauchwerger | Zendy; Guy Raz | Zendy; Mogher Khamaisi | Zendy

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Role of insulin and the IGF system in renal hypertrophy in diabetic Psammomys obesus (sand rat)

Author(s) -

Itamar Raz,

Isaiah D. Wexler,

O Weiss,

A. Flyvbjerg,

Yael Segev,

Adina S. Rauchwerger,

Guy Raz,

Mogher Khamaisi

Publication year - 2003

Publication title -

nephrology dialysis transplantation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.654

H-Index - 168

eISSN - 1460-2385

pISSN - 0931-0509

DOI - 10.1093/ndt/gfg170

Subject(s) - endocrinology , medicine , diabetic nephropathy , diabetes mellitus , renal hypertrophy , kidney , streptozotocin , insulin , nephropathy , kidney disease

Diabetic nephropathy is caused by multiple factors related to the altered metabolic environment in diabetes mellitus (DM). Experimental diabetic kidney disease is characterized by renal hypertrophy associated with increased tissue concentrations of insulin-like growth factor I (IGF-I). To assess the specific roles of serum insulin and glucose in mediating the development of diabetic nephropathy, the effects of both hyperinsulinaemic and hypoinsulinaemic DM were studied in Psammomys obesus (sand rat), a model of type 2 DM.

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