Open AccessHigh serum concentrations of the acyclovir main metabolite 9-carboxymethoxymethylguanine in renal failure patients with acyclovir-related neuropsychiatric side effects: an observational study
Author(s) -
Anders Helldén,
Ingegerd OdarCederlöf,
Per Diener,
Lisbeth Barkholt,
Charlotte Medin,
JanOlof Svensson,
Juliette Säwe,
Lars Ståhle
Publication year - 2003
Publication title -
nephrology dialysis transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.654
H-Index - 168
eISSN - 1460-2385
pISSN - 0931-0509
DOI - 10.1093/ndt/gfg119
Subject(s) - medicine , confidence interval , metabolite , observational study , adverse effect , creatinine , gastroenterology , area under the curve , receiver operating characteristic
Acyclovir (ACV) has been used for over two decades to treat herpes virus infections. Serious neurological adverse side effects have occurred during ACV treatment in patients with renal failure, but the cause of the symptoms remains unknown. We hypothesized that increased concentrations of the ACV main metabolite 9-carboxymethoxymethylguanine (CMMG) correlated to these symptoms.
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