Open AccessIncreased production of chemotactic cytokines and elevated proliferation and expression of intercellular adhesion molecule-1 in rat mesangial cells treated with erythrogenic toxin type B and its precursor isolated from nephritogenic streptococci
Author(s) -
J. Rincón,
Ninoska T. Viera,
Maritza J. Romero,
Jaime Carabalí
Publication year - 2003
Publication title -
nephrology dialysis transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.654
H-Index - 168
eISSN - 1460-2385
pISSN - 0931-0509
DOI - 10.1093/ndt/gfg109
Subject(s) - mesangial proliferative glomerulonephritis , monocyte , mesangial cell , immunofluorescence , chemotaxis , intracellular , microbiology and biotechnology , medicine , cell growth , icam 1 , cell culture , cell adhesion molecule , immunology , glomerulonephritis , biology , kidney , antibody , receptor , biochemistry , genetics
Previous reports have demonstrated the presence of streptococcal erythrogenic toxin type B (ETB) as well as proliferation and expression of adhesion molecules along with leukocyte infiltrations in biopsies from patients with acute post-streptococcal glomerulonephritis (APSGN). The purpose of the present study was to correlate infiltrative and proliferative events with interactions between ETB or its precursor (ETBP) and intrinsic mesangial cells.
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