Dynamics of secretion and metabolism of PTH during hypo- and hypercalcaemia in the dog as determined by the 'intact' and 'whole' PTH assays | Zendy

J. C. Estepa | Zendy; Icíar P. López | Zendy; Arnold J. Felsenfeld | Zendy; Ping Gao | Zendy; Tom Cantor | Zendy; Mariano Rodríguez | Zendy; Escolástico AguileraTejero | Zendy

Open Access

Dynamics of secretion and metabolism of PTH during hypo- and hypercalcaemia in the dog as determined by the 'intact' and 'whole' PTH assays

Author(s) -

J. C. Estepa,

Icíar P. López,

Arnold J. Felsenfeld,

Ping Gao,

Tom Cantor,

Mariano Rodríguez,

Escolástico AguileraTejero

Publication year - 2003

Publication title -

nephrology dialysis transplantation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.654

H-Index - 168

eISSN - 1460-2385

pISSN - 0931-0509

DOI - 10.1093/ndt/gfg104

Subject(s) - parathyroid hormone , hypercalcaemia , endocrinology , medicine , metabolism , calcium

Recent evidence has shown that the assay for 'intact' parathyroid hormone (I-PTH) not only reacts with 1-84 PTH but also with large non-1-84 PTH fragments, most of which is probably 7-84 PTH. As a result, an assay specific for 1-84 PTH named 'whole' PTH (W-PTH) has been developed. The present study was designed: (i) to determine whether the W-PTH assay reliably measures PTH values in the dog; (ii) to evaluate differences between the W-PTH and I-PTH assays during hypo- and hypercalcaemia; and (iii) to assess the peripheral metabolism of W-PTH and I-PTH.

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