Diversity in rat tissue accumulation of vitamin B12 supports a distinct role for the kidney in vitamin B12 homeostasis | Zendy

Henrik Birn | Zendy; Ebba Nexø | Zendy; Erik Christensen | Zendy; Rikke Nielsen | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

Diversity in rat tissue accumulation of vitamin B12 supports a distinct role for the kidney in vitamin B12 homeostasis

Author(s) -

Henrik Birn,

Ebba Nexø,

Erik Christensen,

Rikke Nielsen

Publication year - 2003

Publication title -

nephrology dialysis transplantation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.654

H-Index - 168

eISSN - 1460-2385

pISSN - 0931-0509

DOI - 10.1093/ndt/gfg089

Subject(s) - vitamin b12 , kidney , endocrinology , medicine , homeostasis , spleen , vitamin , cyanocobalamin , endocytosis , distribution (mathematics) , receptor , mathematical analysis , mathematics

Vitamin B(12) in plasma is complexed to the carrier proteins transcobalamin (TC) and haptocorrin. The TC-B(12) complex is filtered in the glomeruli and reabsorbed in the renal tubules by receptor-mediated endocytosis, providing a route for a significant renal accumulation of vitamin B(12). The present study investigates the role of the rodent kidney in B(12) homeostasis by examining the distribution of vitamin B(12) in rats during vitamin B(12) depletion or B(12) load, and compares kidney accumulation with the vitamin distribution in other tissues including brain, liver, testes, intestine, spleen and plasma.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research