Open AccessA compartmental pharmacokinetic model of cyclosporin and its predictive performance after Bayesian estimation in kidney and simultaneous pancreas-kidney transplant recipients
Author(s) -
Serge C.L.M. Cremers,
Eduard M. Scholten,
Rik C. Schoemaker,
Eef G.W.M. Lentjes,
Pieter Vermeij,
Leendert C. Paul,
Jan den Hartigh,
Johan W. de Fijter
Publication year - 2003
Publication title -
nephrology dialysis transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.654
H-Index - 168
eISSN - 1460-2385
pISSN - 0931-0509
DOI - 10.1093/ndt/gfg065
Subject(s) - medicine , pharmacokinetics , urology , population , transplantation , kidney transplantation , area under the curve , dosing , therapeutic drug monitoring , blood sampling , surgery , environmental health
Therapeutic drug monitoring of cyclosporin A (CsA) is an obvious necessity because of its unpredictable absorption and narrow therapeutic window. The use of limited sampling models (LSMs) has improved the estimation of the systemic exposure [area under curve (AUC)] compared with C(0h) monitoring, but these equations are rigid and not reliable in patients with an abnormal absorption profile. We developed and validated a limited sampling (t=0, 2 and 3 h) strategy, based on a compartmental population pharmacokinetic (PK) model for CsA after kidney transplantation alone (KTA) and simultaneous pancreas-kidney transplant (SPKT) recipients, a group of patients with unpredictable absorption kinetics.
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