Polymorphisms of the tumour necrosis factor gene at position -308 and TNFd microsatellite in primary IgA nephropathy | Zendy

Serhan Tuğlular | Zendy; P Berthoux | Zendy; F. Berthoux | Zendy

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Polymorphisms of the tumour necrosis factor gene at position -308 and TNFd microsatellite in primary IgA nephropathy

Author(s) -

Serhan Tuğlular,

P Berthoux,

F. Berthoux

Publication year - 2003

Publication title -

nephrology dialysis transplantation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.654

H-Index - 168

eISSN - 1460-2385

pISSN - 0931-0509

DOI - 10.1093/ndt/gfg010

Subject(s) - tumor necrosis factor alpha , allele , nephropathy , medicine , immunology , gene polymorphism , gene , biology , genetics , endocrinology , diabetes mellitus

The development of glomerular inflammation in immunoglobulin A nephropathy (IgAN) has been associated with various cytokines, including tumour necrosis factor alpha (TNFalpha). A biallelic polymorphism in the promoter region of the TNFalpha gene (TNFA), at position -308, has been described (TNFA-1 and TNFA-2) and is associated with increased TNFalpha production for the TNFA-2 allele. Another microsatellite polymorphism has been described for TNFd, which is functional and associated with increased production of TNFalpha for the d3 allele.

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