Effect of the proton-pump Inhibitor pantoprazole on MycoPhenolic ACid exposure in kidney and liver transplant recipienTs (IMPACT study): a randomized trial | Zendy

A.J. Sunderland | Zendy; Graeme Russ | Zendy; Benedetta C. Sallustio | Zendy; Matthew Cervelli | Zendy; David A. Joyce | Zendy; Esther Ooi | Zendy; Gary P. Jeffrey | Zendy; Neil Boudville | Zendy; Aron Chakera | Zendy; Gursharan Dogra | Zendy; Doris Chan | Zendy; Germaine Wong | Zendy; Wai H. Lim | Zendy

Open Access

Effect of the proton-pump Inhibitor pantoprazole on MycoPhenolic ACid exposure in kidney and liver transplant recipienTs (IMPACT study): a randomized trial

Author(s) -

A.J. Sunderland,

Graeme Russ,

Benedetta C. Sallustio,

Matthew Cervelli,

David A. Joyce,

Esther Ooi,

Gary P. Jeffrey,

Neil Boudville,

Aron Chakera,

Gursharan Dogra,

Doris Chan,

Germaine Wong,

Wai H. Lim

Publication year - 2020

Publication title -

nephrology dialysis transplantation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.654

H-Index - 168

eISSN - 1460-2385

pISSN - 0931-0509

DOI - 10.1093/ndt/gfaa111

Subject(s) - medicine , pantoprazole , mycophenolic acid , proton pump inhibitor , placebo , gastroenterology , mycophenolate , transplantation , adverse effect , pharmacokinetics , kidney transplantation , interquartile range , urology , omeprazole , alternative medicine , pathology

Mycophenolic acid (MPA) is widely utilized as an immunosuppressant in kidney and liver transplantation, with reports suggesting an independent relationship between MPA concentrations and adverse allograft outcome. Proton-pump inhibitors (PPIs) may have variable effects on the absorption of different MPA formulations leading to differences in MPA exposure.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research