Time course of the antiproteinuric and antihypertensive effect of losartan in diabetic nephropathy | Zendy

Steen Andersen | Zendy; Peter Karl Jacobsen | Zendy; Lise Tarnow | Zendy; Peter Rossing | Zendy; Tina R. Juhl | Zendy; Hans Henrik Parving | Zendy

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Time course of the antiproteinuric and antihypertensive effect of losartan in diabetic nephropathy

Author(s) -

Steen Andersen,

Peter Karl Jacobsen,

Lise Tarnow,

Peter Rossing,

Tina R. Juhl,

Hans Henrik Parving

Publication year - 2003

Publication title -

nephrology dialysis transplantation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.654

H-Index - 168

eISSN - 1460-2385

pISSN - 0931-0509

DOI - 10.1093/ndt/18.2.293

Subject(s) - medicine , losartan , diabetic nephropathy , creatinine , renal function , blood pressure , albuminuria , urology , endocrinology , plasma renin activity , angiotensin ii receptor antagonist , angiotensin ii , renin–angiotensin system , kidney

Blockade of the renin-angiotensin system is the primary target in the treatment of diabetic kidney disease. Angiotensin II subtype 1 (AT1) receptor antagonists reduce albuminuria and lower blood pressure, but the initial time course of these effects after initiation of treatment is unknown. We evaluated the time course of the antihypertensive and antialbuminuric effect after initiation of AT1 receptor blockade by losartan in diabetic nephropathy.

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