Open AccessThe role of PC-1 and ACE genes in diabetic nephropathy in type 1 diabetic patients: evidence for a polygenic control of kidney disease progression
Author(s) -
Salvatore De Cosmo
Publication year - 2002
Publication title -
nephrology dialysis transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.654
H-Index - 168
eISSN - 1460-2385
pISSN - 0931-0509
DOI - 10.1093/ndt/17.8.1402
Subject(s) - medicine , diabetic nephropathy , microalbuminuria , renal function , endocrinology , kidney disease , proteinuria , nephropathy , genotype , diabetes mellitus , creatinine , type 2 diabetes , diabetic retinopathy , gastroenterology , kidney , gene , biology , genetics
The DD genotype of the ACE gene predisposes to faster diabetic nephropathy (DN) progression but its role in DN development is more controversial. We reported previously, in type 1 diabetic patients, an association between faster DN progression and the PC-1 gene Q121 variant, which associates with insulin resistance in non-diabetic subjects. We investigated here whether the combination of the ACE DD genotype and the PC-1 Q121 variant predicts the development and/or progression of DN in type 1 diabetic patients.
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