Open AccessProteinuria patterns and their association with subsequent end-stage renal disease in IgA nephropathy
Author(s) -
James V. Donadío
Publication year - 2002
Publication title -
nephrology dialysis transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.654
H-Index - 168
eISSN - 1460-2385
pISSN - 0931-0509
DOI - 10.1093/ndt/17.7.1197
Subject(s) - medicine , proteinuria , end stage renal disease , hazard ratio , nephropathy , dialysis , creatinine , proportional hazards model , renal function , gastroenterology , kidney disease , hemodialysis , renal biopsy , kidney , endocrinology , diabetes mellitus , confidence interval
Proteinuria (UP) >1.0 g/24 h at diagnosis is a well-known indicator of progressive renal disease in patients with IgA nephropathy (IgAN). To determine if persistent UP is a more sensitive marker for later progression of IgAN, the hypothesis was tested that the prior level and trend (slope) in UP for 1 year was better at predicting later end-stage renal disease (ESRD) (dialysis or transplant) than a current 24-h UP, serum creatinine (SC), SC slope, hypertension, or total glomerular histopathological score on index renal biopsy in an observational study of 154 high-risk patients enrolled in two clinical trials (IgAN 1, IgAN 2).
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