Defective calcium signalling in uraemic platelets and its amelioration with long-term erythropoietin therapy | Zendy

Xin J. Zhou | Zendy; Nosratola D. Vaziri | Zendy

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Defective calcium signalling in uraemic platelets and its amelioration with long-term erythropoietin therapy

Author(s) -

Xin J. Zhou,

Nosratola D. Vaziri

Publication year - 2002

Publication title -

nephrology dialysis transplantation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.654

H-Index - 168

eISSN - 1460-2385

pISSN - 0931-0509

DOI - 10.1093/ndt/17.6.992

Subject(s) - medicine , platelet , erythropoietin , endocrinology , thrombin , calcium , platelet activation , felodipine , placebo , blood pressure , pathology , alternative medicine

Chronic renal failure (CRF) is associated with prolonged bleeding time and impaired platelet adhesion and aggregation. Erythropoietin (Epo) administration improves platelet adhesion/aggregation and ameliorates prolongation of bleeding time in CRF. However, the mechanisms of improved platelet function after Epo therapy have not been fully elucidated. The present study examined the hypothesis that the improved uraemic platelet function after Epo therapy is, in part, due to correction of the platelet calcium signalling.

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