Open AccessIn vitro evaluation of motilin agonism by macrolide immunosuppressive drugs
Author(s) -
Bruno Van Vlem
Publication year - 2002
Publication title -
nephrology dialysis transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.654
H-Index - 168
eISSN - 1460-2385
pISSN - 0931-0509
DOI - 10.1093/ndt/17.6.973
Subject(s) - motilin , tacrolimus , medicine , sirolimus , endocrinology , pharmacology , duodenum , erythromycin , antrum , transplantation , chemistry , stomach , biochemistry , antibiotics
The immunosuppressive drugs tacrolimus and sirolimus may have a stimulatory influence on gastric emptying, in view of their macrolide structure. The aim of this study was to investigate in vitro the possible interaction of tacrolimus and sirolimus with motilin receptors in the rabbit antrum and duodenum.
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