Open AccessDual blockade of the renin-angiotensin system in type 1 patients with diabetic nephropathy
Author(s) -
Peter Karl Jacobsen
Publication year - 2002
Publication title -
nephrology, dialysis, transplantation/nephrology dialysis transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.654
H-Index - 168
eISSN - 1460-2385
pISSN - 0931-0509
DOI - 10.1093/ndt/17.6.1019
Subject(s) - medicine , irbesartan , albuminuria , renal function , blood pressure , urology , diabetic nephropathy , endocrinology , diabetes mellitus , placebo , angiotensin ii , type 2 diabetes , nephropathy , alternative medicine , pathology
Albuminuria and hypertension are predictors of poor renal and cardiovascular outcome in patients with diabetes. Approximately 30% of type 1 patients with diabetic nephropathy (DN) have albuminuria >1 g/day, and blood pressure >135 and/or >85 mmHg despite antihypertensive therapy with recommended doses of ACE inhibitor (ACEI) and diuretics. We tested the effect of dual blockade of the renin-angiotensin system (RAS) in these patients.