Open AccessCytoskeletal protein expression and regenerative markers in schistosomal nephropathy
Author(s) -
AhmedF El-Koraie
Publication year - 2002
Publication title -
nephrology dialysis transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.654
H-Index - 168
eISSN - 1460-2385
pISSN - 0931-0509
DOI - 10.1093/ndt/17.5.803
Subject(s) - vimentin , myofibroblast , pathology , proliferating cell nuclear antigen , glomerulosclerosis , medicine , extracellular matrix , immunohistochemistry , nephropathy , focal segmental glomerulosclerosis , kidney , glomerulonephritis , biology , endocrinology , proteinuria , fibrosis , microbiology and biotechnology , diabetes mellitus
Progression of renal diseases is related to the abnormal regulation of cellular and extracellular matrix turnover. Other factors in addition to schistosomal antigens may be relevant to the progression of schistosomal nephropathy (SN). The validity of markers of fibroblastic differentiation, alpha smooth muscle actin (alphaSMA), and vimentin, as well as the regenerative activity (PCNA/apoptosis index) in determination of progression of SN in comparison to other forms of non-schistosomal nephropathy (non-SN) is investigated.
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