Combined therapy of tacrolimus and corticosteroids in cyclosporin‐resistant or ‐dependent idiopathic focal glomerulosclerosis: a preliminary uncontrolled study with prospective follow‐up† | Zendy

Alfons Segarra | Zendy; Josefa Vila | Zendy; Leonor Pou | Zendy; Joaquim Majó | Zendy; Antonia Arbós | Zendy; Maite Quiles | Zendy; L Piera | Zendy

Open Access

Combined therapy of tacrolimus and corticosteroids in cyclosporin‐resistant or ‐dependent idiopathic focal glomerulosclerosis: a preliminary uncontrolled study with prospective follow‐up†

Author(s) -

Alfons Segarra,

Josefa Vila,

Leonor Pou,

Joaquim Majó,

Antonia Arbós,

Maite Quiles,

L Piera

Publication year - 2002

Publication title -

nephrology dialysis transplantation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.654

H-Index - 168

eISSN - 1460-2385

pISSN - 0931-0509

DOI - 10.1093/ndt/17.4.655

Subject(s) - medicine , tacrolimus , proteinuria , discontinuation , gastroenterology , focal segmental glomerulosclerosis , prednisone , creatinine , urology , ciclosporin , surgery , transplantation , kidney

Cyclosporin has improved the outcome for steroid-resistant patients with focal glomerulosclerosis, but there is a proportion of patients that are either cyclosporin-resistant or suffer relapses, needing long-term therapy to sustain the remission. In these cases, preliminary reports suggest that tacrolimus could be an alternative therapy, but to date the evidence is limited to small series of patients with no long-term follow-up.

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