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Cyclosporin has improved the outcome for steroid-resistant patients with focal glomerulosclerosis, but there is a proportion of patients that are either cyclosporin-resistant or suffer relapses, needing long-term therapy to sustain the remission. In these cases, preliminary reports suggest that tacrolimus could be an alternative therapy, but to date the evidence is limited to small series of patients with no long-term follow-up.

nephrology, dialysis, transplantation/nephrology dialysis transplantation

Combined therapy of tacrolimus and corticosteroids in cyclosporin‐resistant or ‐dependent idiopathic focal glomerulosclerosis: a preliminary uncontrolled study with prospective follow‐up†