The effect of LPS, uraemia, and haemodialysis membrane exposure on CD14 expression in mononuclear cells and its relation to apoptosis | Zendy

Julia Carracedo | Zendy; Rafael Ramı́rez | Zendy; Alejandro MartínMalo | Zendy; Mariano Rodríguez | Zendy; Pedro Aljama | Zendy

Open Access

The effect of LPS, uraemia, and haemodialysis membrane exposure on CD14 expression in mononuclear cells and its relation to apoptosis

Author(s) -

Julia Carracedo,

Rafael Ramı́rez,

Alejandro MartínMalo,

Mariano Rodríguez,

Pedro Aljama

Publication year - 2002

Publication title -

nephrology dialysis transplantation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.654

H-Index - 168

eISSN - 1460-2385

pISSN - 0931-0509

DOI - 10.1093/ndt/17.3.428

Subject(s) - peripheral blood mononuclear cell , cd14 , apoptosis , annexin , annexin a5 , monocyte , medicine , flow cytometry , microbiology and biotechnology , cell , immunology , cancer research , in vitro , biology , biochemistry

Both uraemia and bioincompatible haemodialysis membranes induce mononuclear cell apoptosis. Recent reports demonstrate that spontaneous apoptosis in normal monocytes is associated with the down-regulation of CD14 molecules, whereas LPS which prevents the down-regulation of CD14 favours monocyte survival. The aim of the present study was to evaluate a possible association between mononuclear cell apoptosis and low expression of CD14 molecules. This study also investigated whether LPS affects mononuclear cell CD14 expression and the apoptosis induced by uraemia and exposure to Cuprophan (CU) membrane.

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