Statins and angiotensin II‐induced vascular injury | Zendy

Ralf Dechend | Zendy; Dominik N. Müller | Zendy; Jeun Koon Park | Zendy; Anette Fiebeler | Zendy; Hermann Haller | Zendy; Friedrich C. Luft | Zendy

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Statins and angiotensin II‐induced vascular injury

Author(s) -

Ralf Dechend,

Dominik N. Müller,

Jeun Koon Park,

Anette Fiebeler,

Hermann Haller,

Friedrich C. Luft

Publication year - 2002

Publication title -

nephrology dialysis transplantation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.654

H-Index - 168

eISSN - 1460-2385

pISSN - 0931-0509

DOI - 10.1093/ndt/17.3.349

Subject(s) - medicine , nitric oxide , endothelial dysfunction , downregulation and upregulation , pharmacology , endothelin 1 , kidney , endothelin receptor , endocrinology , biochemistry , receptor , chemistry , gene

Statins may have pleiotropic properties that complement their cholesterol-lowering effects. These properties include nitric oxide-mediated improvement of endothelial dysfunction and attenuation of endothelin-1 expression, antioxidant effects, antiinflammatory properties, inhibition of cell proliferation with anti-carcinogenic actions in animals, stabilization of atherosclerotic plaques, anti-coagulant effects and inhibition of graft rejection after heart and kidney transplantation w1x. In a remarkable short-term human study, Tsunekawa et al. w2x showed that cerivastatin improved endothelial dysfunction in elderly diabetic men within 3 days, independent of lipid lowering. The effect may have been partly due to upregulation of nitric oxide (NO) production.

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