Multidirectional approach to study peritoneal dialysis fluid biocompatibility in a chronic peritoneal dialysis model in the rat | Zendy

Katarzyna Wieczorowska–Tobis | Zendy; Alicja Połubińska | Zendy; Justyna Wiśniewska | Zendy; Krzysztof Pawlaczyk | Zendy; Małgorzata Kużlan-Pawlaczyk | Zendy; Violetta Filas | Zendy; Andrzej Bręborowicz | Zendy; Dimitrios G. Oreopoulos | Zendy

Open Access

Multidirectional approach to study peritoneal dialysis fluid biocompatibility in a chronic peritoneal dialysis model in the rat

Author(s) -

Katarzyna Wieczorowska–Tobis,

Alicja Połubińska,

Justyna Wiśniewska,

Krzysztof Pawlaczyk,

Małgorzata Kużlan-Pawlaczyk,

Violetta Filas,

Andrzej Bręborowicz,

Dimitrios G. Oreopoulos

Publication year - 2001

Publication title -

nephrology dialysis transplantation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.654

H-Index - 168

eISSN - 1460-2385

pISSN - 0931-0509

DOI - 10.1093/ndt/16.3.655

Subject(s) - peritoneal dialysis , medicine , peritoneum , biocompatibility , peritoneal equilibration test , dialysis , dialysis tubing , urology , pathology , surgery , continuous ambulatory peritoneal dialysis , chemistry , biochemistry , organic chemistry , membrane

Peritoneal dialysis causes the functional and morphological changes in the peritoneum that result from the bioincompatibility of dialysis solutions. We present a model of chronic peritoneal dialysis in the rat that can be used for testing the biocompatibility of dialysis fluids. Methods and Results. Long-term exposure of the peritoneum to dialysis solutions can be performed in rats with implanted peritoneal catheters. Sampling of the dialysate allows the evaluation of intraperitoneal inflammation by examining cell differential and dialysate cytokine levels. Peritoneal permeability can be evaluated at designed time intervals with the peritoneal equilibration test (PET). At the end of dialysis, peritoneal histology is studied with light and electron microscopy.

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