Effect of 6 weeks of vitamin E administration on renal haemodynamic alterations following a single dose of neoral in healthy volunteers | Zendy

Peter Bárány | Zendy; Peter Stenvinkel | Zendy; A. Ottosson-Seeberger | Zendy; Anders Alvestrand | Zendy; Jason D. Morrow | Zendy; Jackson Roberts | Zendy; Abdulla K. Salahudeen | Zendy

Open Access

Effect of 6 weeks of vitamin E administration on renal haemodynamic alterations following a single dose of neoral in healthy volunteers

Author(s) -

Peter Bárány,

Peter Stenvinkel,

A. Ottosson-Seeberger,

Anders Alvestrand,

Jason D. Morrow,

Jackson Roberts,

Abdulla K. Salahudeen

Publication year - 2001

Publication title -

nephrology dialysis transplantation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.654

H-Index - 168

eISSN - 1460-2385

pISSN - 0931-0509

DOI - 10.1093/ndt/16.3.580

Subject(s) - medicine , renal function , renal blood flow , nephrotoxicity , urology , endocrinology , effective renal plasma flow , kidney

A single oral dose of cyclosporin-A (CsA) transiently reduces renal plasma flow (RPF) and glomerular filtration rate (GFR) in transplant patients and, in some patients, chronic administration of CsA leads to renal impairment and fibrosis. Based on experimental studies, several mediators including free radicals have been proposed to account for CsA-nephrotoxicity. We have previously reported that administration of the antioxidant vitamin E in a rat model of chronic CsA-nephrotoxicity reduces renal fibrosis and maintains renal function.

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