Increased intestinal intra‐epithelial T lymphocytes in primary glomerulonephritis | Zendy

Guy Rostoker | Zendy; JeanCharles Delchier | Zendy; MarieThérèse Chaumette | Zendy

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Increased intestinal intra‐epithelial T lymphocytes in primary glomerulonephritis

Author(s) -

Guy Rostoker,

JeanCharles Delchier,

MarieThérèse Chaumette

Publication year - 2001

Publication title -

nephrology dialysis transplantation

Language(s) - Uncategorized

Resource type - Journals

SCImago Journal Rank - 1.654

H-Index - 168

eISSN - 1460-2385

pISSN - 0931-0509

DOI - 10.1093/ndt/16.3.513

Subject(s) - medicine , intraepithelial lymphocyte , glomerulonephritis , coeliac disease , nephropathy , pathology , duodenum , intestinal mucosa , immunoglobulin a , immunology , gastroenterology , immune system , kidney , immunoglobulin g , endocrinology , disease , diabetes mellitus

There is increasing evidence that some organ-specific and generalized autoimmune diseases in humans might be related to a breakdown of oral tolerance. We explored this hypothesis in human primary glomerulonephritides. We prospectively counted intraepithelial T lymphocytes in the duodenal mucosa (as a marker of rupture of oral tolerance), together with IgA1 and IgA2 mucosal plasma cells, in patients with primary glomerulonephritides.

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