Failure of high doses of calcitriol and hypercalcaemia to induce apoptosis in hyperplastic parathyroid glands of azotaemic rats | Zendy

Aquiles Jara | Zendy; Sergio González | Zendy; Arnold J. Felsenfeld | Zendy; Cecilia Chacón | Zendy; Andrés Valdivieso | Zendy; Roberto Jalil | Zendy; B Chuaqui | Zendy

Open Access

Failure of high doses of calcitriol and hypercalcaemia to induce apoptosis in hyperplastic parathyroid glands of azotaemic rats

Author(s) -

Aquiles Jara,

Sergio González,

Arnold J. Felsenfeld,

Cecilia Chacón,

Andrés Valdivieso,

Roberto Jalil,

B Chuaqui

Publication year - 2001

Publication title -

nephrology dialysis transplantation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.654

H-Index - 168

eISSN - 1460-2385

pISSN - 0931-0509

DOI - 10.1093/ndt/16.3.506

Subject(s) - calcitriol , medicine , endocrinology , parathyroid gland , hyperparathyroidism , secondary hyperparathyroidism , parathyroid hormone , hypercalcaemia , hyperplasia , apoptosis , vitamin d and neurology , calcium , biology , biochemistry

Whether calcitriol administration, which is used to treat secondary hyperparathyroidism in dialysis patients, induces regression of parathyroid-gland hyperplasia remains a subject of interest and debate. If regression of the parathyroid gland were to occur, the presumed mechanism would be apoptosis. However, information on whether high doses of calcitriol can induce apoptosis of parathyroid cells in hyperplastic parathyroid glands is lacking. Consequently, high doses of calcitriol were given to azotaemic rats and the parathyroid glands were evaluated for apoptosis.

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