Cyclosporin A affects extracellular matrix synthesis and degradation by mouse MC3T3‐E1 osteoblasts in vitro | Zendy

Alessia Fori | Zendy; Flavia Cornacchia | Zendy; Guy A. Howard | Zendy; Bernard A. Roos | Zendy; Gary E. Striker | Zendy; Liliane J. Striker | Zendy

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Cyclosporin A affects extracellular matrix synthesis and degradation by mouse MC3T3‐E1 osteoblasts in vitro

Author(s) -

Alessia Fori,

Flavia Cornacchia,

Guy A. Howard,

Bernard A. Roos,

Gary E. Striker,

Liliane J. Striker

Publication year - 2001

Publication title -

nephrology dialysis transplantation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.654

H-Index - 168

eISSN - 1460-2385

pISSN - 0931-0509

DOI - 10.1093/ndt/16.3.500

Subject(s) - extracellular matrix , medicine , osteopenia , in vivo , in vitro , extracellular , osteoblast , microbiology and biotechnology , bone remodeling , matrix (chemical analysis) , osteoporosis , biochemistry , bone mineral , biology , chemistry , chromatography

Immunosuppressant therapy is thought to be a major contributor to post-transplant bone disease. Histological data and serum parameters suggest that Cyclosporin A (CsA) treatment causes osteopenia as a result of an altered bone turnover, but the pathogenic mechanisms of this process remain unclear. We investigate if CsA affects cell turnover and extracellular matrix (ECM) synthesis and degradation in MC3T3-E1 osteoblasts, as a surrogate model for in vivo events.

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